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This is a rare reaction wherein patients develop dramatic, sudden and self-limiting thrombocytopenia, typically 7 to 10 days after a blood transfusion.
Patients usually have a history of sensitisation by either pregnancy or transfusion.
While the immune specificity may be to a platelet-specific antigen, both autologous and allogeneic platelets are destroyed.
Demonstrate antiplatelet antibody.
Give intravenous immunoglobulin at 1 g/kg as a total dose and repeat as necessary.(1)
You have to make a request to the Blood Service or Jurisdictional Approver to access IVIg.
Antigen-negative platelets may be indicated if platelet transfusion is required but this is controversial.