Plasma compatibility

Plasma components (eg, fresh frozen plasma, cryoprecipitate or cryodepleted plasma) for transfusion should be compatible with the ABO group of the recipient, to avoid potential haemolysis caused by donor anti-A or anti-B. Matching for the RhD type is not necessary.

Compatible ABO Groups for Plasma Transfusions
Patient’s ABO blood group   ABO blood group of plasma for transfusion Unit ABO Group*
O A B AB
Unknown AB (if required urgently)       1
O O or A or B or AB 1 2 3 4
A A or AB   1   2
B B or AB     1 2
AB AB (A if AB unobtainable)   2   1
Note: *1 = primary choice; 2 to 4 = second, third and last choice where supply of ABO identical plasma is limited; Individual plasma units of different blood groups must not be pooled.