Blood group phenotypes

Alloantibodies causing haemolytic transfusion reactions or haemolytic disease in the fetus and newborn are dependent on the frequency with which alloantigens and alloantibodies occur.
 

Major Blood Group Phenotypes and their Frequencies(1–5)

Phenotype % Frequency
A1 29.7
A2 9.3
B 11.4
O 46.1
A1B 2.3
A2B 1.2
Phenotype % Frequency
MMSS 6
MMss 9.1
MMSs 14.4
MNSS 3
MNss 23.3
MNSs 22.7
NNSS 0.4
NNss 15.6
NNSs 5.5
Phenotype % Frequency
P1+ 74.8
P1 25.2
Phenotype % Frequency
See Rhesus phenotypes  
Phenotype % Frequency
Lu(a+b–) 0.2
Lu(a–b+) 92.3
Lu(a+b+) 7.5
Lu(a–b–) Rare
Phenotype % Frequency
K– k+ 90.9
K+ k– 0.4
K+ k+ 8.7
Kp(a+b–) <0.1
Kp(a–b+) 97.8
Kp(a+b+) 2.2
Phenotype % Frequency
Le(a+b–) 22.4
Le(a–b+) 72.3
Le(a–b–) 5.3
Phenotype % Frequency
Fy(a+b–) 19.7
Fy(a–b+) 32.7
Fy(a+b+) 47.6
Fy(a–b–) very rare
Phenotype % Frequency
Jk(a+b–) 26.3
Jk(a–b+) 23.6
Jk(a+b+) 50.1
Jk(a–b–) rare
Phenotype % Frequency
Di(a+b–) <0.01
Di(a-b+) >99.9
Di(a+b+) <0.1
Wr(a+) <0.01
Wr(b+) High incidence
Phenotype % Frequency
Yt(a+b–) 91.9
Yt(a–b+) 0.3
Yt(a+b+) 7.8
Phenotype % Frequency
Xg(a+) Male-65.6
  Female-88.7
Xg(a–) Male-34.4
  Female-11.3
Phenotype % Frequency
Sc:1,–2 99
Sc:–1,2 Rare
Sc:1,2 1
Sc:1,–2,Rd+ Rare
Sc:1,2,Rd+ Rare
Phenotype % Frequency
Do(a+b–) 18
Do(a–b+) 33
Do(a+b+) 49
Gy(a–) Rare
Phenotype % Frequency
Co(a+b–) 90
Co(a–b+) 0.5
Co(a+b+) 9.5
Phenotype % Frequency
LW(a+b–) 97
LW(a–b+) Rare
LW(a+b+) 3
Phenotype % Frequency
Chido phenotype  
CH/RG: 1,2,3 88.2
CH/RG: 1,–2,3 4.9
CH/RG: 1,2,–3 3.1
CH/RG: –1,–2,–3 3.8
CH/RG: –1,2,-3 Rare
CH/RG: 1,–2,–3 Rare
Rodgers phenotype  
CH/RG: 11,12 95
CH/RG: 11,–12 3
CH/RG: –11,–12 2
Phenotype % Frequency
H High incidence
Phenotype % Frequency
Kx High incidence
Phenotype % Frequency
Ge:2,3,4 >99.9
Ge:–2,3,4 (Yus type) Rare
Ge:–2,–3,4 (Gerbich type) Rare
Ge:–2,–3,–4 (Leach) Rare
Phenotype % Frequency
Cra, Tca, Dra, Esa High Incidence
Tcb, Tcc, WESa Low incidence
Phenotype % Frequency
Kn(a+b–) 94.5
Kn(a–b+) 1
Kn(a+b+) 4.5
McC(a+) 98
Sl(a+) 98
Yk(a+) 92
Phenotype % Frequency
In(a+b–) Rare
In(a–b+) 99.9
In(a+b+) <0.1
Phenotype % Frequency
Ok(a+) 100
Ok(a–) Rare
Phenotype % Frequency
MER2 92
Phenotype % Frequency
JMH High incidence
Phenotype % Frequency
I High incidence
Phenotype % Frequency
P High incidence
Phenotype % Frequency
GIL High incidence
Phenotype % Frequency
Duclos High incidence
Phenotype % Frequency
FORS1 High incidence
Phenotype % Frequency
Jra High incidence
Phenotype % Frequency
Lan High incidence
Phenotype % Frequency
Vel High incidence
Phenotype % Frequency
CD59.1 High incidence
Phenotype % Frequency
AUG1  
AUG2 >99%
Phenotype % Frequency
Csa 95
Csb 34
Era  >99
Erb <1
Er3 >99
Lec 1
Led 6
i  
LKE 98
Hu  
M1  
Tm  
Can  
Sext  
Sj  
Phenotype % Frequency
By, Chra, Bi, Bxa, Pta, Rea, Jea , Lia, RASM, JFV, Kg, JONES, HJK, HOFM, REIT <1
Phenotype % Frequency
Ata, AnWj, Sda >90
Emm, PEL, ABTI, MAM  

Note: Unless indicated, frequencies are based on blood group statistics of Australian blood donors; ** Frequency is based on Caucasian population.

 

References
  1. Daniels DL, Fletcher A, Garratty G, Henry S, Jorgensen J, Judd WJ et al. Blood group terminology from the International Society of Blood Transfusion committee on terminology for red cell surface antigens. Vox Sanguinis 2004;87:304–316.
  2. Garratty G, Dzik W, Issitt PD, Lublin DM, Reid ME, Zelinski T. Terminology for blood group antigens and genes - historical origins and guidelines in the new millennium. Transfusion 2004;40:477–489.
  3. Reid ME, Lomas-Francis C. Blood Group Antigens & Antibodies - A guide to clinical relevance and technical tips. SBB Books, New York, 2007.
  4. Seqirus. Antibody and antigen characteristics
  5. International Society of Blood Transfusion (ISBT). Red cell immonogenetics and blood group terminology. [cited 2016 Jun 27]. Available from: http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/