Use of cryoprecipitate

The component contains most of the factor VIII, fibrinogen, factor XIII, von Willebrand factor and fibronectin from fresh frozen plasma.

Cryoprecipitate is indicated for the treatment of fibrinogen deficiency or dysfibrinogenaemia when there is clinical bleeding, an invasive procedure, trauma or disseminated intravascular coagulation.


Do not use cryoprecipitate for the treatment of haemophilia, von Willebrand’s disease or deficiencies of factor XIII or fibronectin unless alternative therapies are unavailable.


Volume depends on clinical situation, patient size and laboratory tests. A common dose for fibrinogen replacement is 30–40 mL cryoprecipitate for each 10 kg patient body weight.

Discuss with your Haematologist or a Blood Service Medical Officer.

For patients with specific factor deficiencies, always consider specific replacement therapy (eg, factor VIII for haemophilia A, rather than cryoprecipitate).