Fresh frozen plasma

Asset 13b-Plasma_0.jpgFresh frozen plasma (FFP) can be derived from either a collection of whole blood or apheresis plasma.

To be suitable for clinical purposes, whole blood plasma must be separated from the whole blood unit preferably within 6 hours and not more than 18 hours after collection. The freezing process must commence within 18 hours of collection.

FFP Paediatric is derived from a single unit of whole blood. When requested the plasma is separated and then divided into four packs of equal volume. This reduces donor exposure for small paediatric transfusions and minimises product wastage.

For apheresis plasma to be suitable for clinical purposes the freezing process should commence within 6 hours of completion of the collection procedure. All apheresis FFP is split into 2 or 3 units of equal volume prior to freezing.

All FFP must be frozen to a core temperature below –30º C within 1 hour of commencement of the freezing process.

A unit of FFP contains all coagulation factors including the labile plasma coagulation Factors VIII and V. An adult dose contains approximately 200 IU of Factor VIII.

FFP can be stored for 12 months at –25º C or below.

 

Typical unit content and specifications

Information is based on the typical unit content (mean ± 1 SD) from Blood Service data (1 April 2015 to 31 March 2016 inclusive) and acceptable specification limits (in parentheses).

Volume (mL)
284 ± 13 (250–310)
Platelet Count (109/L)
8 ± 4 (< 50)
Leucocyte Count (109/L)
0.04 ± 0.04 (< 0.1)
Factor VIIIc (IU/mL)
1.05 ± 0.16 (> 0.70)
Volume (mL)
70 ± 3 (60–80)
Volume (mL)
274 ± 11 (250–310)
Platelet Count (109/L)
16 ± 10 (< 50)
Leucocyte Count (109/L)
0.03 ± 0.01 (< 0.1)
Factor VIIIc (IU/mL)
1.26 ± 0.15 (> 0.70)

 

Availability

This component is available in all ABO groups.

 

Modifications

An adult dose of fresh frozen plasma can be modified as IgA deficient, low titre anti-T and secretor.
There are no modifications for paediatric doses.

 

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