Intravenous immunoglobulin (IVIg)

Intravenous immunoglobulin (IVIg) is a solution of human plasma proteins and in particular IgG antibodies with a broad spectrum of antibody activity. IVIg is prepared from large pools of human plasma collected from several thousand blood donors and contains all the typical IgG antibodies found in the normal population. IVIg is used for patients who need replacement of antibodies and also for autoimmune disorders.

IVIg can be obtained under National Blood Supply or Direct Order arrangements. Refer to the National Blood Authority website about the supply of IVIg in Australia.

 

Criteria for the clinical use of intravenous immunoglobulin

Intravenous immunoglobulin (IVIg) is issued in accordance with the Criteria for the Clinical Use of Intravenous Immunoglobulin in Australia (2nd edition; 2012).

The Criteria describe the conditions and circumstances for which IVIg is funded under the national blood supply arrangements.

 

IVIg Authorisation Request forms

IVIg “Authorisation Request Forms” for access to government funded immunoglobulin products are available in all states and territories.

The forms are available on the National Blood Authority website.The forms have two pages that will need to be completed by the Prescriber and submitted to the Australian Red Cross Blood Service or other approved delegate, for assessment for access to government funded immunoglobulin product, in accordance with the criteria for clinical use.

Intragam® P is the domestically (Australian) manufacturing IVIg product and is accessed user the National Blood Supply (NBS) arrangements.

Intragam® P is available as a 6% solution in vial sizes 3g/50 mL and 12g/200 mL and is supplied by CSL Behring.

Refer to the Criteria for the Clinical Use of IVIg for specific indications and product information sheet for further information.

Information on ordering and pricing is outlined in the National Blood Authority website.

Intragam® P product information

This link takes you to CSL Behring's web information about Intragam® P where you can download the product information (PI) sheet for this product. The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage & administration of Intragam® P.

► Read the infusion rate for Intragam® P

Privigen® is an imported IVIg product.

Privigen® is available as a 10% solution in vial sizes 5g/50 mL, 10g/100 mL, 20g/200 mL and 40g/400 mL and is supplied by CSL Behring.

Refer to the Criteria for the Clinical Use of IVIg for specific indications and product information sheet for further information.

Information on ordering and pricing is outlined in the National Blood Authority website.

Privigen® product information and educational materials

This link takes you to CSL Behring's web information about Privigen®  where you can download the product information (PI) sheet for this product. The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage & administration of Privigen®. You can also download an order form to request copies of educational materials.

Flebogamma® is an imported IVIg product. Flebogamma® is supplied by Grifols and is available in both 5% and 10% formulations.

Refer to the Criteria for the Clinical Use of IVIg for specific indications and product information sheet for further information.

Information on ordering and pricing is outlined in the National Blood Authority website.

 

Flebogamma® 5% DIF

Flebogamma® 5% DIF is available in vial sizes 0.5g/10 mL, 2.5g/50 mL, 5g/100 mL, 10g/200 mL and 20g/400 mL.

Flebogamma® 5% product information

This link takes you to Grifol's web information about Flebogamma® 5% DIF where you can download the product information (PI) sheet for this product. The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage and administration of Flebogamma® 5% DIF.

 

Flebogamma® 10% DIF

Flebogamma® 10% DIF is available in vial sizes 5g/50 mL, 10g/100 mL and 20g/200 mL.

Flebogamma® 10% product information

This link takes you to Grifol's web information about Flebogamma® 10% DIF where you can download the product information (PI) sheet for this product. The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage and administration of Flebogamma® 10% DIF.

Octagam® is a plasma-derived intravenous immunoglobulin solution available as a 5% formulation and 10% formulation. IVIg is used for patients who need replacement of antibodies and also for autoimmune disorders.

Refer to the Criteria for the Clinical Use of IVIg for specific indications and product information sheet for further information.

This is an imported product that is used to meet any shortfalls in the availability of domestically-produced Intragam® P.

Information on ordering and pricing is outlined in the National Blood Authority website.

► Read the Octagam® Administration Information for Clinicians and Nurses

 

Octagam® 5%

► Read the infusion rate calculator for Octagam® 5%

Octagam® 5% product information

This link takes you to Octapharma's web information about Octagam® 5%. You can download the product information (PI) sheet from this web page.
The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage & administration of Octagam® 5%.

 

Octagam® 10%

► Read the infusion rate calculator for Octagam® 10%

Octagam® 10% product information

This link takes you to Octapharma's web information about Octagam® 10%. You can download the product information (PI) sheet from this web page.
The PI details the pharmacology, indications, contraindications, precautions, adverse effects, use in pregnancy & lactation, and dosage & administration of Octagam® 10%.

Kiovig 10% is a plasma-derived intravenous immunoglobulin solution. This is an imported product supplied by Baxalta. IVIg is used for patients who need replacement of antibodies and also for autoimmune disorders.

► Read the infusion rate calculator for Kiovig 10%

Refer to the Criteria for the Clinical Use of IVIg for specific indications and product information sheet for further information.

This is an imported product. Information on ordering and pricing is outlined in the National Blood Authority website.

IVIg can be obtained under National Blood Supply or Direct Order arrangements. Refer to the National Blood Authority website about the supply of IVIg in Australia.

Supply of plasma derived and recombinant blood products factsheet

 

Availability of Octagam 5%, Octagam 10% and Kiovig 10%

Octagam® 5%, Octagam® 10% and Kiovig 10% will not be available to order under the national blood supply arrangements for new patients after 31 December 2015; however, these products will continue to be available to order for existing patients until 30 June 2016. Any patients who require ongoing treatment beyond 30 June 2016 will need to be transitioned to another IVIg product, i.e. Privigen®, Flebogamma® 5% DIF or Flebogamma 10% DIF.

Further information on supply arrangements for imported Ig products in Australia is available on the National Blood Authority website.

 

Forthcoming change to Australia’s domestically produced IVIg

INTRAGAM® 10 to replace INTRAGAM® P, commencing February 2017

The National Blood Authority (NBA) advises a forthcoming change to Australia’s domestically produced intravenous immunoglobulin (IVIg) product. During the first half of 2017, the 10% concentration ‘INTRAGAM 10’ will be introduced and will eventually replace the current 6% ‘INTRAGAM P’.

INTRAGAM 10 will provide lower volume doses for patients compared with the same Ig dose of INTRAGAM P.

 

Further information

The Australian Immunisation Handbook 10th edition recommends that immunoglobulin containing blood products, apart from RhD Immunoglobulin (“Anti-D”), should not be administered for 3 weeks following vaccination with live attenuated vaccines. MMR containing vaccines should not be given for 3-11 months following the receipt of immunoglobulin containing blood products. Further information regarding all vaccines should be obtained from the Australian Immunisation Handbook 10th edition.

Prescription of these products often requires specialist consultation. Always read and refer to the product information sheet of every product prior to administration.

► Download the Comparison of Intragam® P, Privigen® and Flebogamma®

► Download the Comparison of Intragam® P, Kiovig10%, Octagam® 5% and Octagam® 10%

► Download weekly orders forms

► Supply of plasma derived and recombinant blood products factsheet