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|Prothrombinex®-VF (500 IU)|
Warfarin is used for preventing and treating venous or arterial thrombosis and embolism.
Warfarin blocks the gamma-carboxylation of glutamic acid residues of Vitamin K−dependent coagulation factors.
This blockage inhibits synthesis of Vitamin K−dependent coagulation factors, resulting in decreased biological activity of factors II, VII, IX, X, and protein C and protein S; with prolongation of the international normalised ratio (INR).
Warfarin is a potentially hazardous drug that causes major bleeding, including intracranial haemorrhage, in 1.2%–8.1% of patients during each year of long-term warfarin therapy.(1)