Does my patient require irradiated blood components?

Transfusion associated graft versus host disease (TA-GvHD) is a rare and life threatening transfusion reaction that may occur in immunocompromised patients following the transfusion of cellular components. This complication can also occur in immunocompetent patients if HLA homology is present between recipient and donor. The outcome is nearly always fatal.

The use of irradiated components has been proven to reduce the incidence of TA-GvHD and is indicated in a number of clinical conditions.

This tool provides health professionals with guidance on situations when the use of irradiated cellular components is appropriate. This guidance may not be appropriate in all patient situations, and individual circumstances may dictate an alternative approach.

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